PLITIDEPSIN AS A SUCCESSFUL RESCUE TREATMENT FOR PROLONGED VIRAL SARS-COV-2 REPLICATION IN A PATIENT WITH PREVIOUS ANTI-CD20 MONOCLONAL ANTIBODY-MEDIATED B CELL DEPLETION AND CHRONIC LYMPHOCYTIC LEUKEMIA

Plitidepsin as a successful rescue treatment for prolonged viral SARS-CoV-2 replication in a patient with previous anti-CD20 monoclonal antibody-mediated B cell depletion and chronic lymphocytic leukemia

Abstract Background There is an urgent need for highly efficacious antiviral therapies in immunosuppressed hosts who develop coronavirus disease (COVID-19), with special concern for those affected by hematological malignancies.Case presentation Here, we report the case of a 75-year-old male with chronic Hoodie lymphocytic leukemia who was deficient

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GENETIC EPILEPSY WITH FEBRILE SEIZURES PLUS CAUSED BY SCN1A GENE MUTATION: A FAMILY REPORT AND LITERATURE REVIEW

Objective To summarize the clinical features and treatment of genetic epilepsy with febrile seizures plus (GEFS+) caused by SCN1A gene mutations, to improve the understanding of SCN1A gene mutations, and to provide a basis for the clinical diagnosis and treatment of this disease.Methods Clinical data were collected from a child with GEFS+ and her f

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